New nasal spray effective against XBB, other Covid variants

New nasal spray effective against XBB, other Covid variants

Europe News Desk!! Researchers in Finland have developed a molecule that when given nasally is highly effective in preventing disease caused by all known variants of the SARS-CoV-2 virus, which currently includes the XBB variant. Researchers from the University of Helsinki in Finland said the molecule, known as TriSB92, could be an important tool in preparing for future pandemics, as it aims to block both the transmission and spread of the virus. They found that TriSB92 recognizes a region in the spike protein of Covid, which is common to all existing forms of the virus, and inhibits its function. In addition, animal models have demonstrated that face masks, unlike the molecule, when sprayed into the nose, can prevent infection even after a few hours of exposure.

Postdoctoral researcher Anna R. When administered nasally, the triSB92 molecule is highly effective at inhibiting infection, Makela said, and experiments in cell culture indicate that it also contains the very latest variants, including XBB, Bf7 and Bq.1.1. Are. In a paper published in the journal Nature Communications, the researchers said the molecule remained fully functional at room temperature for at least 18 months, making it suitable for use as a nasal spray. While the worst phase of the coronavirus pandemic is, at least for the time being, behind us, nasally-administered protection could be an important help in preventing the spread of the virus in the future. The latest variants effectively avoid the immune protection provided by both the vaccine and the COVID-19 disease, Makela said, and existing vaccines are not effective in preventing transmission.

In addition, the nasal spray can protect against serious illness in people who do not get enough immunity from vaccines, such as the immunocompromised and the elderly. According to the researchers, the molecule may also work against future animal-borne close relatives of SARS-CoV-2, which is expected to cause an entirely new coronavirus pandemic. Makela said, the spike protein affected by the TRISB92 molecule in the region of the corona virus has remained almost unchanged in all viral variants that have emerged so far, it can also be considered effective against future SARS-CoV-2 variants. “Easily and cheaply produced TriSB92 could prove to be very effective in preventing such a new pandemic, pending the development, production and distribution of vaccines,” he said. The researchers said the technique used in developing the molecule could also be applicable to the prevention of many other viral diseases, particularly influenza and other respiratory viruses. The next step could be to test the molecule in clinical trials, after which it could be made commercially available, he added.

–IANS

SGK/ANM

World News Desk!!

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